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Revelation 16:12
And the sixth angel poured out his vial upon the great river Euphrates; and the water thereof was dried up, that the way of the kings of the east might be prepared. (Revelation 16:12)
1-21 (Revelation 6:13-17; Psalm 46:1-3; Matthew 24:7). John Witnessed Terrors of the Last Days
 John ... was a witness of the terrible scenes that will take place as signs of Christ’s coming. He saw armies mustering for battle, and men’s hearts failing them for fear. He saw the earth moved out of its place, the mountains carried into the midst of the sea, the waves thereof roaring and troubled, and the mountains shaking with the swelling thereof. He saw the vials of God’s wrath opened, and pestilence, famine, and death come upon the inhabitants of the earth (The Review and Herald, January 11, 1887).