One of the first to fall was Isaiah, who for over half a century had stood before Judah as the appointed messenger of Jehovah. “Others had trial of cruel mockings and scourgings, yea, moreover of bonds and imprisonment: they were stoned, they were sawn asunder, were tempted, were slain with the sword: they wandered about in sheepskins and goatskins; being destitute, afflicted, tormented; (of whom the world was not worthy:) they wandered in deserts, and in mountains, and in dens and caves of the earth.” Hebrews 11:36-38. (PK 382.1) MC VC

Some of those who suffered persecution during Manasseh’s reign were commissioned to bear special messages of reproof and of judgment. The king of Judah, the prophets declared, “hath done wickedly above all ... which were before him.” Because of this wickedness, his kingdom was nearing a crisis; soon the inhabitants of the land were to be carried captive to Babylon, there to become “a prey and a spoil to all their enemies.” 2 Kings 21:11, 14. But the Lord would not utterly forsake those who in a strange land should acknowledge Him as their Ruler; they might suffer great tribulation, yet He would bring deliverance to them in His appointed time and way. Those who should put their trust wholly in Him would find a sure refuge. (PK 382.2) MC VC

Faithfully the prophets continued their warnings and their exhortations; fearlessly they spoke to Manasseh and to his people; but the messages were scorned; backsliding Judah would not heed. As an earnest of what would befall the people should they continue impenitent, the Lord permitted their king to be captured by a band of Assyrian soldiers, who “bound him with fetters, and carried him to Babylon,”(2 Chronicles 33:11) their temporary capital. This affliction brought the king to his senses; “he besought the Lord his God, and humbled himself greatly before the God of his fathers, and prayed unto Him: and He was entreated of him, and heard his supplication, and brought him again to Jerusalem into his kingdom. Then Manasseh knew that the Lord He was God.” 2 Chronicles 33:11-13. But this repentance, remarkable though it was, came too late to save the kingdom from the corrupting influence of years of idolatrous practices. Many had stumbled and fallen, never again to rise. (PK 382.3) MC VC

Among those whose life experience had been shaped beyond recall by the fatal apostasy of Manasseh, was his own son, who came to the throne at the age of twenty-two. Of King Amon it is written: “He walked in all the way that his father walked in, and served the idols that his father served, and worshiped them: and he forsook the Lord God of his fathers” (2 Kings 21:21, 22); he “humbled not himself before the Lord, as Manasseh his father had humbled himself; but Amon trespassed more and more.” The wicked king was not permitted to reign long. In the midst of his daring impiety, only two years from the time he ascended the throne, he was slain in the palace by his own servants; and “the people of the land made Josiah his son king in his stead.” 2 Chronicles 33:23, 25. (PK 383.1) MC VC